Cisplatin inactivation of caspases inhibits death ligand-induced cell death in vitro and fulminant liver damage in mice.

@article{Shin2005CisplatinIO,
  title={Cisplatin inactivation of caspases inhibits death ligand-induced cell death in vitro and fulminant liver damage in mice.},
  author={Jin Na Shin and Young Woo Seo and Moonil Kim and Sun-Young Park and Mi-ja Lee and Byung Rai Lee and J Oh and Dai-wu Seol and T Kim},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 11},
  pages={10509-15}
}
Cisplatin is a platinum-containing chemotherapeutic drug that has been widely used to treat various human cancers. It acts by forming inter- and intracross-links of DNA, which is believed to be a major cause for its therapeutic efficacy. However, little attention has been paid to the effect of cisplatin on death ligand-induced cell death. Here we demonstrate that cisplatin inhibits death ligand-induced cell death in cell lines in a p53-independent manner. This inhibitory effect of cisplatin on… CONTINUE READING
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