Cisplatin dose intensity.

  title={Cisplatin dose intensity.},
  author={Robert F. Ozols},
  journal={Seminars in oncology},
  volume={16 4 Suppl 6},
The dose intensity of cisplatin is an important factor in achieving optimal therapeutic results, particularly in ovarian and testicular cancer. Pharmacologic techniques have permitted dose escalation to 200 mg/m2 per cycle. However, further escalations in cisplatin dose are not currently possible due to the development of dose-limiting peripheral neuropathy. Clinical studies are currently in progress with agents such as WR2721 and diethyldithiocarbamate which, in experimental models of cancer… CONTINUE READING


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