Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro.

@article{Palm2011CisplatinBH,
  title={Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro.},
  author={Maria E Palm and Christoph F. Weise and Christina Lundin and Gunnar Wingsle and Yvonne Nygren and Erik Bj{\"o}rn and Peter Naredi and Magnus Wolf-Watz and Pernilla Wittung-Stafshede},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 17},
  pages={6951-6}
}
Cisplatin (cisPt), Pt(NH(3))(2)Cl(2), is a cancer drug believed to kill cells via DNA binding and damage. Recent work has implied that the cellular copper (Cu) transport machinery may be involved in cisPt cell export and drug resistance. Normally, the Cu chaperone Atox1 binds Cu(I) via two cysteines and delivers the metal to metal-binding domains of ATP7B; the ATP7B domains then transfer the metal to the Golgi lumen for loading on cuproenzymes. Here, we use spectroscopic methods to test if… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

Crystal structures of cisplatin bound to a human copper chaperone.

Journal of the American Chemical Society • 2009
View 4 Excerpts
Highly Influenced

Solution structure of the apo and copper(I)-loaded human metallochaperone HAH1

I Anastassopoulou
Biochemistry • 2004
View 3 Excerpts
Highly Influenced

Pt-195 NMR kinetic and mechanistic studies of cis-diamminedichloroplatinum and trans-diamminedichloroplatinum(Ii) binding to DNA

DP Bancroft, CA Lepre, SJ Lippard
J Am Chem Soc 112:6860–6871 • 1990
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…