Cisplatin augments FAS-mediated apoptosis through lipid rafts.

  title={Cisplatin augments FAS-mediated apoptosis through lipid rafts.},
  author={Cheng-Ri Huang and Zhe-Xiong Jin and Lingli Dong and Xiao-Peng Tong and Sun Yue and Takafumi Kawanami and Toshioki Sawaki and Tomoyuki Sakai and Miyuki Miki and Haruka Iwao and Akio Nakajima and Yasufumi Masaki and Yoshihiko Fukushima and Masao Tanaka and Yoshimasa Fujita and Hideo Nakajima and Toshiro Okazaki and Hisanori Umehara},
  journal={Anticancer research},
  volume={30 6},
Cisplatin is widely and effectively used for the treatment of various types of cancer. However, its biochemical mechanisms are still unelucidated. Previously, we reported that membrane sphingomyelin (SM) was important for FAS-mediated apoptosis through lipid raft function. In this study, we strikingly show that cisplatin combined with CH11 (anti-FAS… CONTINUE READING