Cisplatin-associated nephrotoxicity and pathological events.

@article{Taguchi2005CisplatinassociatedNA,
  title={Cisplatin-associated nephrotoxicity and pathological events.},
  author={T. Taguchi and A. Nazneen and M. Abid and M. Razzaque},
  journal={Contributions to nephrology},
  year={2005},
  volume={148},
  pages={
          107-21
        }
}
Cisplatin (cis-diamminedichloroplatinum(II)) is an effective chemotherapeutic agent, and is successfully used in the treatment of a wide range of tumors. Despite its effectiveness as an anti-tumor drug, nephrotoxic side effects have significantly restricted its clinical use. Tubular epithelial cell deletion following cisplatin treatment is a major cause of renal injury. Oxidative stress significantly contributes to cisplatin-associated cytotoxicity, and use of antioxidants could counteract such… Expand
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