Cisplatin-associated nephrotoxicity and pathological events.

  title={Cisplatin-associated nephrotoxicity and pathological events.},
  author={Takashi Taguchi and Arifa Nazneen and M. Ruhul Abid and Mohammed S Razzaque},
  journal={Contributions to nephrology},
Cisplatin (cis-diamminedichloroplatinum(II)) is an effective chemotherapeutic agent, and is successfully used in the treatment of a wide range of tumors. Despite its effectiveness as an anti-tumor drug, nephrotoxic side effects have significantly restricted its clinical use. Tubular epithelial cell deletion following cisplatin treatment is a major cause of renal injury. Oxidative stress significantly contributes to cisplatin-associated cytotoxicity, and use of antioxidants could counteract such… 

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