Cisplatin and resveratrol induce apoptosis and autophagy following oxidative stress in malignant mesothelioma cells.

@article{Lee2016CisplatinAR,
  title={Cisplatin and resveratrol induce apoptosis and autophagy following oxidative stress in malignant mesothelioma cells.},
  author={Yoon-Jin Lee and Gina J Lee and Sun Shin Yi and Su-Hak Heo and Cheon Gu Park and Hae-Seon Nam and Moon-Kyun Cho and Sang Han Lee},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2016},
  volume={97},
  pages={
          96-107
        }
}
Malignant mesothelioma (MM) is characterized by poor responsiveness to current chemotherapeutic drugs, usually owing to high resistance to apoptosis. Here, we investigated chemosensitizing effects of phytochemical resveratrol, in combination with cisplatin, on MM cells. The combination treatment of cisplatin and resveratrol (CDDP/RSV) synergistically induced apoptosis, as evidenced by typical cell morphological changes, the appearance of sub-G0/G1 peak, an increase in the Annexin V(+) cells and… CONTINUE READING

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