Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family).

@article{Yonezawa2006CisplatinAO,
  title={Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family).},
  author={Atsushi Yonezawa and Satohiro Masuda and Sachiko Yokoo and Toshiya Katsura and Ken-ichi Inui},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2006},
  volume={319 2},
  pages={879-86}
}
We have examined the role of the human organic cation transporters [hOCTs and human novel organic cation transporter (hOCTN); SLC22A1-5] and apical multidrug and toxin extrusion (hMATE) in the cellular accumulation and cytotoxicity of platinum agents using the human embryonic kidney (HEK) 293 cells transiently transfected with the transporter cDNAs. Both the cytotoxicity and accumulation of cisplatin were enhanced by the expression of hOCT2 and weakly by hOCT1, and those of oxaliplatin were… CONTINUE READING
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