Cisplatin and fluorouracil as neoadjuvant therapy in head and neck cancer. A preliminary report.

@article{Toohill1987CisplatinAF,
  title={Cisplatin and fluorouracil as neoadjuvant therapy in head and neck cancer. A preliminary report.},
  author={Robert James Toohill and T. Anderson and Roger W. Byhardt and James D. Cox and James A. Duncavage and Theodore Grossman and Charles D. Haas and Jennifer S. Haas and Arthur J. Hartz and J A Libnoch},
  journal={Archives of otolaryngology--head & neck surgery},
  year={1987},
  volume={113 7},
  pages={758-61}
}
A randomized, prospective trial utilizing cisplatin and fluorouracil as neoadjuvant chemotherapy in the treatment of advanced squamous cell carcinomas of the upper aerodigestive tract was initiated in January 1983. Sixty patients were stratified by site (oral cavity, 19; larynx, 14; hypopharynx, 14; oropharynx, 11; nasopharynx, one; and paranasal sinuses, one) and by stage (III, 19; IV, 41), and then randomized to receive either standard treatment (defined as preoperative irradiation followed… CONTINUE READING