Cisplatin and Oxaliplatin, but Not Carboplatin and Nedaplatin, Are Substrates for Human Organic Cation Transporters (SLC22A1–3 and Multidrug and Toxin Extrusion Family)

@article{Yonezawa2006CisplatinAO,
  title={Cisplatin and Oxaliplatin, but Not Carboplatin and Nedaplatin, Are Substrates for Human Organic Cation Transporters (SLC22A1–3 and Multidrug and Toxin Extrusion Family)},
  author={Atsushi Yonezawa and Satohiro Masuda and Sachiko Yokoo and Toshiya Katsura and Ken-ichi Inui},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2006},
  volume={319},
  pages={879 - 886}
}
  • A. Yonezawa, S. Masuda, K. Inui
  • Published 1 November 2006
  • Biology, Chemistry
  • Journal of Pharmacology and Experimental Therapeutics
We have examined the role of the human organic cation transporters [hOCTs and human novel organic cation transporter (hOCTN); SLC22A1–5] and apical multidrug and toxin extrusion (hMATE) in the cellular accumulation and cytotoxicity of platinum agents using the human embryonic kidney (HEK) 293 cells transiently transfected with the transporter cDNAs. Both the cytotoxicity and accumulation of cisplatin were enhanced by the expression of hOCT2 and weakly by hOCT1, and those of oxaliplatin were… 

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[Platinum agent-induced nephrotoxicity via organic cation transport system].
  • A. Yonezawa
  • Biology, Chemistry
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
  • 2012
TLDR
Oxaliplatin, which was a superior substrate of the luminal efflux transporter, MATE2-K as well as OCT2, did not show nephrotoxicity and carboplatin and nedaplatin were not transported by these transporters.
The human organic cation transporter OCT1 mediates high affinity uptake of the anticancer drug daunorubicin
TLDR
Using the high-grade serous ovarian cancer cell line TOV2223G, it is shown that OCT1 mediated the high affinity uptake of daunorubicin into the cells, and that micromolar amounts of choline completely abolished the drug entry.
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