Cisplatin Nephrotoxicity: A Review

@article{Yao2007CisplatinNA,
  title={Cisplatin Nephrotoxicity: A Review},
  author={X. Yao and K. Panichpisal and N. Kurtzman and K. Nugent},
  journal={The American Journal of the Medical Sciences},
  year={2007},
  volume={334},
  pages={115-124}
}
Background:Cisplatin is a major antineoplastic drug for the treatment of solid tumors, but it has dose-dependent renal toxicity. Methods:We reviewed clinical and experimental literature on cisplatin nephrotoxicity to identify new information on the mechanism of injury and potential approaches to prevention and/or treatment. Results:Unbound cisplatin is freely filtered at the glomerulus and taken up into renal tubular cells mainly by a transport-mediated process. The drug is at least partially… Expand
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  • B. Humanes, S. Camaño, +5 authors A. Lázaro
  • Medicine
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2017
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Newer Insights into Cisplatin Nephrotoxicity
Cisplatin nephrotoxicity is mediated by deoxyribonuclease I.
Cisplatin nephrotoxicity.
Metabolism of Cisplatin to a nephrotoxin in proximal tubule cells.
Magnesium depletion enhances cisplatin-induced nephrotoxicity.
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