Cisplatin-Induced Downregulation of OCTN2 Affects Carnitine Wasting

  title={Cisplatin-Induced Downregulation of OCTN2 Affects Carnitine Wasting},
  author={Cynthia S. Lancaster and Chaoxin Hu and Ryan M. Franke and Kelly K. Filipski and Shelley Orwick and Zhaoyuan Chen and Zhili Zuo and Walter J. Loos and Alex Sparreboom},
  journal={Clinical Cancer Research},
  pages={4789 - 4799}
Purpose: Carnitine is an essential cofactor for mitochondrial fatty acid oxidation that is actively reabsorbed by the luminal transporter Octn2 (Slc22a5). Because the nephrotoxic agent cisplatin causes urinary loss of carnitine in humans, we hypothesized that cisplatin may affect Octn2 function. Experimental Design: Excretion of carnitine and acetylcarnitine was measured in urine collected from mice with or without cisplatin administration. The transport of carnitine was assessed in cells that… 

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