Cisplatin Enhances Hepatitis B Virus Replication and PGC-1α Expression through Endoplasmic Reticulum Stress

@inproceedings{Li2018CisplatinEH,
  title={Cisplatin Enhances Hepatitis B Virus Replication and PGC-1α Expression through Endoplasmic Reticulum Stress},
  author={Xiaosong Li and En Pan and Junke Zhu and Lei Xu and Xuemei Chen and Jingjing Li and Li Liang and Y Hu and Jie Xia and Juan Chen and Wannan Chen and Jieli Hu and Kundong Wang and Ni Tang and Ailong Huang},
  booktitle={Scientific Reports},
  year={2018}
}
Chronic hepatitis B infection remains a serious public health issue worldwide. Hepatitis B virus (HBV) reactivation is commonly reported in patients receiving anticancer therapy, immunosuppressive therapy, or organ and tissue transplantation. However, the precise mechanisms underlying chemotherapeutic agent-related HBV reactivation remain unclear. Here, we report that peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) plays a central role in cisplatin-induced HBV… CONTINUE READING
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