Cisplatin Activates Volume-Sensitive Like Chloride Channels Via Purinergic Receptor Pathways in Nasopharyngeal Carcinoma Cells

@article{Yang2014CisplatinAV,
  title={Cisplatin Activates Volume-Sensitive Like Chloride Channels Via Purinergic Receptor Pathways in Nasopharyngeal Carcinoma Cells},
  author={Xiaoya Yang and Linyan Zhu and Jiawei Lin and Shanwen Liu and Hai Luo and Jianwen Mao and Sihuai Nie and Li-xin Chen and Liwei Wang},
  journal={The Journal of Membrane Biology},
  year={2014},
  volume={248},
  pages={19-29}
}
Cisplatin-based concomitant chemoradiotherapy is considered as the standard treatment for locally advanced nasopharyngeal carcinoma patients. However, the curative efficacy of cisplatin-based chemotherapy is limited because of the occurrence of cisplatin resistance. Some researches indicate that activating the volume-sensitive Cl− channel might be a new strategy for the reduction of cisplatin resistance. However, little is known about the activation pathway of the Cl− channels activated by… CONTINUE READING

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Highly Influenced

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