Cisplatin: mode of cytotoxic action and molecular basis of resistance

@article{Siddik2003CisplatinMO,
  title={Cisplatin: mode of cytotoxic action and molecular basis of resistance},
  author={Zahid H. Siddik},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={7265-7279}
}
Cisplatin is one of the most potent antitumor agents known, displaying clinical activity against a wide variety of solid tumors. Its cytotoxic mode of action is mediated by its interaction with DNA to form DNA adducts, primarily intrastrand crosslink adducts, which activate several signal transduction pathways, including those involving ATR, p53, p73, and MAPK, and culminate in the activation of apoptosis. DNA damage-mediated apoptotic signals, however, can be attenuated, and the resistance… CONTINUE READING
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