Cisplatin: from DNA damage to cancer chemotherapy.

@article{Cohen2001CisplatinFD,
  title={Cisplatin: from DNA damage to cancer chemotherapy.},
  author={Samuel M. Cohen and Stephen J Lippard},
  journal={Progress in nucleic acid research and molecular biology},
  year={2001},
  volume={67},
  pages={
          93-130
        }
}
Cisplatin [cis-DDP, cis-diamminedichloroplatinum(II)] is a potent anticancer drug that has been used successfully to treat tumors of the head, neck, lungs, and genitourinary tract. The biological activity of cisplatin was discovered serendipitously more than 30 years ago, and since that time research efforts have focused on elucidating its mechanism of action. The present review provides a historical perspective of our attempts to understand this complex phenomenon and the results of recent… CONTINUE READING

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