Cis-urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2A receptor.

@article{Walterscheid2006CisurocanicAA,
  title={Cis-urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2A receptor.},
  author={Jeffrey P. Walterscheid and Dat X. Nghiem and Nasser Kazimi and Leta K. Nutt and David James McConkey and Mary Norval and Stephen E. Ullrich},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 46},
  pages={17420-5}
}
Exposure to UV radiation induces skin cancer and suppresses the immune response. To induce immune suppression, the electromagnetic energy of UV radiation must be absorbed by an epidermal photoreceptor and converted into a biologically recognizable signal. Two photoreceptors have been recognized: DNA and trans-urocanic acid (UCA). Trans-UCA is normally found in the outermost layer of skin and isomerizes to the cis isomer upon exposure to UV radiation. Although UCA was identified as a UV… CONTINUE READING

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References

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Showing 1-6 of 6 references

Immu- nology 115:289–295

  • EJ Meredith, A Chamba, MJ Holder, NM Barnes, J Gordon
  • 2005
2 Excerpts

Front Biosci

  • V Shreedhar, T Giese, VW Sung, SE Ullrich
  • 2002

Photochem Photobiol

  • M Norval, J Garssen, H VanLoveren, AA el-Ghorr
  • 1996

Photochem Photobiol 64:269–274

  • J Garssen, W Goettsch, F de Gruijl, W Slob, H van Loveren
  • 1996
1 Excerpt

Photochem Photobiol 62:209–217

  • M Norval, NK Gibbs, J Gilmour
  • 1995
1 Excerpt

CA Cancer J Clin

  • MS Fisher, ML Kripke
  • 1992

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