Cis-trans complementation of DQA1-DQB1 genes are modulated by DQ alleles: an immunogenetics analysis of DQ association with the down-regulatory function of CD8 cells in trichosanthin-induced immunosuppression.

@article{Chou1999CistransCO,
  title={Cis-trans complementation of DQA1-DQB1 genes are modulated by DQ alleles: an immunogenetics analysis of DQ association with the down-regulatory function of CD8 cells in trichosanthin-induced immunosuppression.},
  author={Kuang Yen Chou and Shu-lan Fu and Ning Li and Linong Huang and F Q Wang and P. H. Lu and Lieying Fan},
  journal={European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics},
  year={1999},
  volume={26 1},
  pages={5-13}
}
The initiation of a CD8 cell-mediated pathway (M+) was adopted as a phenotypic trait to analyse genetic predisposition in trichosanthin (Tk)-induced immuno-suppression. Tk is a natural protein antigen with 247 amino acid residues. Based on DNA typing for DR, DQ, DP and TAP genes, data in this paper indicate that only DQ genes were primarily involved and that the alleles DQA1*0501 and DQB1*0201 were strongly associated with the M+ phenotype in cis (on DR3 haplotype) or trans (on DR5/DR7… CONTINUE READING