Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence

@article{Wittkopp2012CisregulatoryEM,
  title={Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence},
  author={Patricia J. Wittkopp and Gizem Kalay},
  journal={Nature Reviews Genetics},
  year={2012},
  volume={13},
  pages={59-69}
}
Cis-regulatory sequences, such as enhancers and promoters, control development and physiology by regulating gene expression. Mutations that affect the function of these sequences contribute to phenotypic diversity within and between species. With many case studies implicating divergent cis-regulatory activity in phenotypic evolution, researchers have recently begun to elucidate the genetic and molecular mechanisms that are responsible for cis-regulatory divergence. Approaches include detailed… 
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