Cis-polyunsaturated fatty acids stimulate beta1 integrin-mediated adhesion of human breast carcinoma cells to type IV collagen by activating protein kinases C-epsilon and -mu.

Abstract

We have investigated the effects of various fatty acids (FAs) on integrin-mediated MDA-MB-435 breast carcinoma cell adhesion to type IV collagen (collagen IV) in vitro. Arachidonic acid (AA) and linoleic acid both induced a dose-dependent increase in cell adhesion to collagen IV with no significant increase in nonspecific adhesion to polylysine and BSA… (More)

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@article{Palmantier2001CispolyunsaturatedFA, title={Cis-polyunsaturated fatty acids stimulate beta1 integrin-mediated adhesion of human breast carcinoma cells to type IV collagen by activating protein kinases C-epsilon and -mu.}, author={R Palmantier and Margaret D George and Steven K. Akiyama and Frances M. Wolber and Kenneth Olden and John D. Roberts}, journal={Cancer research}, year={2001}, volume={61 6}, pages={2445-52} }