Cis-diamminedichloroplatinum (II). A new anticancer drug.

  title={Cis-diamminedichloroplatinum (II). A new anticancer drug.},
  author={Marcel Rozencweig and Daniel D. Von Hoff and Milan Slavik and Franco M. Muggia},
  journal={Annals of internal medicine},
  volume={86 6},
Cis-diamminedichloroplatinum (II) (DDP) leads the series of platinum coordination complexes, a new class of cytotoxic agents. The antitumor and toxic effects of this drug are discussed. It has displayed encouraging results in testicular tumors. The drug's therapeutic effectiveness has also been recognized in a variety of other solid tumors, particularly ovarian, bladder, and head and neck malignancies. Gastrointestinal, renal, audiologic, and relatively minor hematologic toxicities may be… CONTINUE READING