Cis control of gene expression in E.coli by ribosome queuing at an inefficient translational stop signal.

@article{Jin2002CisCO,
  title={Cis control of gene expression in E.coli by ribosome queuing at an inefficient translational stop signal.},
  author={Haining Jin and Asgeir Bj{\"o}rnsson and Leif A. Isaksson},
  journal={The EMBO journal},
  year={2002},
  volume={21 16},
  pages={
          4357-67
        }
}
An UGA stop codon context which is inefficient because of the 3'-flanking context and the last two amino acids in the gene protein product has a negative effect on gene expression, as shown using a model protein A' gene. This is particularly true at low mRNA levels, corresponding to a high intracellular ribosome/mRNA ratio. The negative effect is smaller if this ratio is decreased, or if the distance between the initiation and termination signals is increased. The results suggest that an… CONTINUE READING
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