Cis association of Ly49A with MHC class I restricts natural killer cell inhibition

  title={Cis association of Ly49A with MHC class I restricts natural killer cell inhibition},
  author={M. -A. Doucey and L{\'e}onardo Scarpellino and Jacques Zimmer and Philippe Guillaume and Immanuel F. Luescher and Claude Bron and Werner Held},
  journal={Nature Immunology},
Natural killer (NK) cell function is negatively regulated by inhibitory receptors interacting with major histocompatibility complex class I molecules expressed on target cells. Here we show that the inhibitory Ly49A NK cell receptor not only binds to its H-2Dd ligand expressed on potential target cells (in trans) but also is constitutively associated with H-2Dd in cis (on the same cell). Cis association and trans interaction occur through the same binding site. Consequently, cis association… CONTINUE READING


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