Cis- and trans-acting functions required for endocytosis of the yeast pheromone receptors

@article{Davis1993CisAT,
  title={Cis- and trans-acting functions required for endocytosis of the yeast pheromone receptors},
  author={Nicholas G. Davis and Joseph Horecka and George F. Sprague},
  journal={The Journal of Cell Biology},
  year={1993},
  volume={122},
  pages={53 - 65}
}
The Saccharomyces cerevisiae a-factor receptor (STE3) is subject to two modes of endocytosis: a constitutive process that occurs in the absence of ligand and a regulated process that is triggered by binding of ligand. Both processes result in delivery of the receptor to the vacuole for degradation. Receptor mutants deleted for part of the COOH-terminal cytoplasmic domain are disabled for constitutive, but not ligand-dependent internalization. Trans-acting mutants that impair constitutive… CONTINUE READING
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Constitu - tive mutants of the protein kinase STE 11 activate the yeast pheromone response pathway in the absence of the G protein

  • K. Tatchell, K. A. Nasmyth, B. D. Hall
  • Genes & Dev .
  • 1992

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