Cis- and trans-acting elements involved in the regulation of the erythroid promoter of the human porphobilinogen deaminase gene.

@article{Mignotte1989CisAT,
  title={Cis- and trans-acting elements involved in the regulation of the erythroid promoter of the human porphobilinogen deaminase gene.},
  author={Vincent Mignotte and J F El{\'e}ouet and Natacha Raich and P. H. Romeo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 17},
  pages={
          6548-52
        }
}
Two cis-acting sequences, recognized by two erythroid-specific trans-acting factors, are involved in the regulation of the erythroid promoter of the human gene coding for porphobilinogen deaminase (PBGD). The first region, located at -70, binds the erythroid factor NF-E1, and point mutations within this region abolish the induction of transcription of this promoter during murine erythroleukemia (MEL) cell differentiation. The second region, located at -160, binds the erythroid-specific factor… CONTINUE READING
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