Cis-acting sequences responsive to the rev gene product of the human immunodeficiency virus.

@article{Dayton1988CisactingSR,
  title={Cis-acting sequences responsive to the rev gene product of the human immunodeficiency virus.},
  author={Andrew I. Dayton and Ernest F. Terwilliger and J L Potz and Mark Kowalski and Joseph Sodroski and William A. Haseltine},
  journal={Journal of acquired immune deficiency syndromes},
  year={1988},
  volume={1 5},
  pages={441-52}
}
Expression of high levels of the structural proteins of the human immunodeficiency virus type 1 (HIV-1) requires the presence of two regulatory genes, the trans-activator (tat), and the regulator of virion protein expression (rev. previously called art or trs). The experiments described here show that expression of virion proteins is dependent upon a small region located in the envelope gene called the cis-acting antirepression sequence (CAR). The CAR region of the envelope sequence is both… CONTINUE READING

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