Cis‐Regulatory Elements Controlling Basal and Inducible VIP Gene Transcription

@article{Hahm1998CisRegulatoryEC,
  title={Cis‐Regulatory Elements Controlling Basal and Inducible VIP Gene Transcription},
  author={Sung Ho Hahm and Lee E. Eiden},
  journal={Annals of the New York Academy of Sciences},
  year={1998},
  volume={865}
}
  • S. H. Hahm, L. Eiden
  • Published 1 December 1998
  • Biology
  • Annals of the New York Academy of Sciences
Abstract: The cis‐acting elements of the VIP gene important for basal and stimulated transcription have been studied by transfection of VIP‐reporter gene constructs into distinct human neuroblastoma cell lines in which VIP transcription is constitutively high, or can be induced to high levels by protein kinase stimulation. The 5.2 kb flanking sequence of the VIP gene conferring correct basal and inducible VIP gene expression onto a reporter gene in these cell lines was systematically deleted to… 

A restrictive element 1 (RE‐1) in the VIP gene modulates transcription in neuronal and non‐neuronal cells in collaboration with an upstream tissue specifier element

TLDR
A repressor element, similar to the canonical restrictive element‐1 (RE‐1), located within the first non‐coding exon of the human VIP gene is reported, which can regulate VIP reporter gene expression in neuroblastoma and fibroblastic cells.

Computational promoter analysis of mouse, rat and human antimicrobial peptide-coding genes

TLDR
A large-scale computational analysis of promoters of 22 families of AMPcgs across three mammalian species suggests that their key transcriptional regulators are likely to be TFs of the liver-, nervous system-specific and NHR groups.

Calcium signal‐mediated expression of the vasoactive intestinal polypeptide gene and its small contribution to activity‐dependent survival of mouse cerebellar granule cells

TLDR
It is demonstrated that expression of vasoactive intestinal polypeptide (VIP), a member of the same VIP/secretin/glucagon family as PACAP, was activated markedly by Ca2- influx through L‐type voltage‐dependent Ca2+ channels (L‐VDCCs), which could be induced under the depolarizing condition induced by high concentration of potassium in the medium.

Phorbol esters dPPA/dPA promote furin expression involving transcription factor CEBPβ in neuronal cells.

TLDR
Results suggested that in neuronal cells, transcriptional activation of furin by dPPA/dPA may be initiated by C1 domain containing proteins including PKC; the intracellular signaling involves ERK and PI3K and transcription factor CEBPβ.

VPAC1 couples with TRPV4 channel to promote calcium-dependent gastric cancer progression via a novel autocrine mechanism

TLDR
It is demonstrated that VPAC1 is significantly overexpressed in gastric cancer andVPAC1/TRPV4/Ca2+ signaling axis could enforce a positive feedback regulation in Gastric cancer progression.

References

SHOWING 1-10 OF 52 REFERENCES

Tissue‐Specific Expression of the Vasoactive Intestinal Peptide Gene Requires Both an Upstream Tissue Specifier Element and the 5′ Proximal Cyclic AMP‐Responsive Element

TLDR
F Forskolin‐mediated induction of the reporter gene in SH‐EP and SK‐N‐SH cells was completely abolished by mutations in the VIP‐CRE but not by deletion of the upstream sequence, indicating that the VIP•CRE alone determines cyclic AMP responsiveness.

Five Discrete Cis-active Domains Direct Cell Type-specific Transcription of the Vasoactive Intestinal Peptide (VIP) Gene*

TLDR
Five discrete domains of the VIP gene provide a combination of enhancer and repressor activities, each completely contingent on VIP gene context, that together result in cell-specific transcription of the Vanity peptide gene.

The LIM family transcription factor Isl-1 requires cAMP response element binding protein to promote somatostatin expression in pancreatic islet cells.

TLDR
The ability of CREB to function in a phosphorylation-independent manner suggests a mechanism by which this protein can regulate gene transcription.

The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation

TLDR
The p68c-ets-1 protein cooperates with c-Fos and c-Jun (components of AP-1) for activation of transcription from the oncogene-responsive domain of the polyoma enhancer, indicating that combined activity of all three oncoproteins could be involved in the response of cells to growth stimuli.

The POU homeodomain transcription factor Oct-1 is essential for activity of the gonadotropin-releasing hormone neuron-specific enhancer

The mechanisms of specification of gene expression in a complex tissue such as the brain remain poorly understood. To provide a model system for the study of gene regulation in a specific

The POU domain: versatility in transcriptional regulation by a flexible two-in-one DNA-binding domain.

TLDR
How the structural flexibility of the bipartite POU domain leads to flexible interactions with DNA and other proteins and, thus, functional versatility in transcriptional regulation is discussed.

Cell Type-specific Regulation of Choline Acetyltransferase Gene Expression ROLE OF THE NEURON-RESTRICTIVE SILENCER ELEMENT AND CHOLINERGIC-SPECIFIC ENHANCER SEQUENCES*

TLDR
Positive and negative regulatory elements within a 2336-base pairlong region of the rat choline acetyltransferase (ChAT) gene promoter that cooperate to direct cell type-specific expression in cholinergic cells are demonstrated.

Quantitative analysis of the expression of a VIP transgene.

...