Circumventricular Organs: Gateways to the BrainLeptin Receptors In Hypothalamus And Circumventricular Organs

  title={Circumventricular Organs: Gateways to the BrainLeptin Receptors In Hypothalamus And Circumventricular Organs},
  author={Björn Meister and Marie-louise H{\aa}kansson},
  journal={Clinical and Experimental Pharmacology and Physiology},
  • B. Meister, M. Håkansson
  • Published 1 July 2001
  • Biology, Medicine
  • Clinical and Experimental Pharmacology and Physiology
1. The adipose tissue‐derived hormone leptin reduces food intake and bodyweight via leptin receptors (Ob‐R) in the hypothalamus. 
The subfornical organ: a central nervous system site for actions of circulating leptin.
The presence of mRNA for the signaling form of the leptin receptor in SFO and leptin receptor localization by immunohistochemistry within this CVO identifies the SFO as a possible central nervous system location, with direct access to the peripheral circulation, at which leptin may act to influence hypothalamic control of energy homeostasis.
Cross-talk between reproduction and energy homeostasis: central impact of estrogens, leptin and kisspeptin signaling
Progress made in understanding the interactions between reproduction and energy homeostasis is reviewed by focusing on the advances made to understand the cellular signaling of E2 and leptin on three neural networks: kisspeptin, pro-opiomelanocortin (POMC) and neuropeptide Y (NPY).
Metabolic signaling to the central nervous system: routes across the blood brain barrier.
Alternative mechanisms through which one specific circulating adipokine, leptin, can gain access to and influence central nervous sites involved in the regulation of energy homeostasis without the requirement for direct access from the peripheral circulation to arcuate neurons are considered.
From sensory circumventricular organs to cerebral cortex: Neural pathways controlling thirst and hunger
The insula and anterior cingulate cortex, as well as several other cortical sites, have been implicated in the conscious perception of thirst and hunger in humans and are identified as likely sites of synaptic links in pathways from the subfornical organ and OVLT to the cortex.
Differential modulation of energy balance by leptin, ciliary neurotrophic factor, and leukemia inhibitory factor gene delivery: microarray deoxyribonucleic acid-chip analysis of gene expression.
Evidence is presented that constitutive expression of cytokines in the brain induces changes in gene expression characteristic of chronic inflammation leading to either temporal weight reduction (CNTF) or severe cachexia (leukemia inhibitory factor).
Estrogen signaling in hypothalamic circuits controling reproduction


Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus
Interactions of leptin with brain mechanisms and immunohistochemical results show extensive distribution of LR-like immunoreactivity (LR-LI) in the brain with positively stained cells present, e.g., in the choroid plexus, cerebral cortex, hippocampus, thalamus, and hypothalamus.
The role of neuropeptide Y in the antiobesity action of the obese gene product
RECENTLY Zhang et al.1 cloned a gene that is expressed only in adipose tissue of the mouse. The obese phenotype of theob/ob mouse is linked to a mutation in the obese gene that results in expression
The loop system between neuropeptide Y and leptin in normal and obese rodents.
The etiologic viewpoint of a pivotal role of the hypothalamus in obesity syndromes has been strengthened by the discovery of one hypothalamic neuropeptide and one peripheral (adipose tissue) hormone, respectively neuropeptic Y and leptin.
Coexpression of Leptin Receptor and Preproneuropeptide Y mRNA in Arcuate Nucleus of Mouse Hypothalamus
Dual in situ hybridization studies for leptin receptor and NPY gene expression in the mouse arcuate nucleus are reported, providing the first direct evidence that leptin acts on cells that express NPY mRNA.
Localization of leptin receptor (Ob-R) messenger ribonucleic acid in the rodent hindbrain.
A number of rodent hindbrain sites expressing the leptin receptor gene are activated by circulating leptin and may form a monitoring/signaling pathway to complement more direct hypothalamic interactions.
Leptin injected into the fourth ventricle inhibits gastric emptying
The data indicate that leptin acts centrally to suppress gastric emptying possibly via leptin receptors located on cholinergic DMX neurones.
Localization of leptin receptor mRNA expression in mouse brain.
The distribution of the leptin receptor in the brain of C57 mice was investigated using a non-radioactive in situ hybridization method and the localization of leptin receptor-containing neurones in the present study indicates the possibility that the leptin receptors are expressed on neuropeptide Y-containing neurons.