Circumventricular Organs: Gateways to the BrainLeptin Receptors In Hypothalamus And Circumventricular Organs

@article{Meister2001CircumventricularOG,
  title={Circumventricular Organs: Gateways to the BrainLeptin Receptors In Hypothalamus And Circumventricular Organs},
  author={Björn Meister and Marie-louise H{\aa}kansson},
  journal={Clinical and Experimental Pharmacology and Physiology},
  year={2001},
  volume={28}
}
  • B. Meister, M. Håkansson
  • Published 1 July 2001
  • Biology, Medicine
  • Clinical and Experimental Pharmacology and Physiology
1. The adipose tissue‐derived hormone leptin reduces food intake and bodyweight via leptin receptors (Ob‐R) in the hypothalamus. 
The subfornical organ: a central nervous system site for actions of circulating leptin.
TLDR
The presence of mRNA for the signaling form of the leptin receptor in SFO and leptin receptor localization by immunohistochemistry within this CVO identifies the SFO as a possible central nervous system location, with direct access to the peripheral circulation, at which leptin may act to influence hypothalamic control of energy homeostasis.
Cross-talk between reproduction and energy homeostasis: central impact of estrogens, leptin and kisspeptin signaling
TLDR
Progress made in understanding the interactions between reproduction and energy homeostasis is reviewed by focusing on the advances made to understand the cellular signaling of E2 and leptin on three neural networks: kisspeptin, pro-opiomelanocortin (POMC) and neuropeptide Y (NPY).
Metabolic signaling to the central nervous system: routes across the blood brain barrier.
TLDR
Alternative mechanisms through which one specific circulating adipokine, leptin, can gain access to and influence central nervous sites involved in the regulation of energy homeostasis without the requirement for direct access from the peripheral circulation to arcuate neurons are considered.
From sensory circumventricular organs to cerebral cortex: Neural pathways controlling thirst and hunger
TLDR
The insula and anterior cingulate cortex, as well as several other cortical sites, have been implicated in the conscious perception of thirst and hunger in humans and are identified as likely sites of synaptic links in pathways from the subfornical organ and OVLT to the cortex.
Differential modulation of energy balance by leptin, ciliary neurotrophic factor, and leukemia inhibitory factor gene delivery: microarray deoxyribonucleic acid-chip analysis of gene expression.
TLDR
Evidence is presented that constitutive expression of cytokines in the brain induces changes in gene expression characteristic of chronic inflammation leading to either temporal weight reduction (CNTF) or severe cachexia (leukemia inhibitory factor).
Estrogen signaling in hypothalamic circuits controling reproduction
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Interactions of leptin with brain mechanisms and immunohistochemical results show extensive distribution of LR-like immunoreactivity (LR-LI) in the brain with positively stained cells present, e.g., in the choroid plexus, cerebral cortex, hippocampus, thalamus, and hypothalamus.
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TLDR
A number of rodent hindbrain sites expressing the leptin receptor gene are activated by circulating leptin and may form a monitoring/signaling pathway to complement more direct hypothalamic interactions.
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TLDR
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TLDR
The distribution of the leptin receptor in the brain of C57 mice was investigated using a non-radioactive in situ hybridization method and the localization of leptin receptor-containing neurones in the present study indicates the possibility that the leptin receptors are expressed on neuropeptide Y-containing neurons.
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