Circumvention of the induction of resistance in murine experimental autoimmune thyroiditis by recombinant IL-1 beta.

@article{Nabozny1992CircumventionOT,
  title={Circumvention of the induction of resistance in murine experimental autoimmune thyroiditis by recombinant IL-1 beta.},
  author={Gerald H. Nabozny and Yi-chi M. Kong},
  journal={Journal of immunology},
  year={1992},
  volume={149 3},
  pages={1086-92}
}
Murine experimental autoimmune thyroiditis (EAT) is induced in genetically susceptible mice by immunization with mouse thyroglobulin (MTg). We have previously shown that raising the level of circulatory MTg for greater than or equal to 2 to 3 days, by the i.v. injection of soluble MTg or the infusion of thyroid-stimulating hormone, rendered these mice resistant to subsequent EAT induction. The Ag-specific resistance was mediated by CD4+ Ts cells, and the induction of unresponsiveness could be… CONTINUE READING

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