Circumvention of outer surface protein A immunity by host-adapted Borrelia burgdorferi.

@article{Barthold1995CircumventionOO,
  title={Circumvention of outer surface protein A immunity by host-adapted Borrelia burgdorferi.},
  author={Stephen W. Barthold and Erol Fikrig and Linda K Bockenstedt and David H. Persing},
  journal={Infection and immunity},
  year={1995},
  volume={63 6},
  pages={2255-61}
}
Outer surface protein A (OspA), which is abundantly expressed in cultured Borrelia burgdorferi, appears to be down-regulated or masked following low-dose infection, and OspA immunization did not prevent infection, dissemination, or disease development with host-adapted spirochetes. Seroconversion of mice to B. burgdorferi OspA depended on dose and viability of inoculated spirochetes. Mice inoculated with > 10(4) live spirochetes and > 10(7) heat-killed spirochetes seroconverted to OspA, but… CONTINUE READING

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