Circumvention of drug resistance in cancer cells by a new fluoropyrimidine analogue

Abstract

The potentiation of antitumor drugs by their analogues is one of strategies for overcoming cellular resistance to chemotherapy. In attempts to improve the efficacy of 5-fluorouracil (5-FU) and overcome 5-FU resistance, we synthesized new 5- FU derivatives and evaluated the potentiation effect on 5-FU cytotoxicity. 5-Fluorouracil-1-yl-3-butanone (5-FUBO), a… (More)
DOI: 10.1038/emm.1996.18

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@article{Kim1996CircumventionOD, title={Circumvention of drug resistance in cancer cells by a new fluoropyrimidine analogue}, author={Sun Hee Kim and Chi Dug Kang and Byung Seon Chung and Jack C. Kim}, journal={Experimental & Molecular Medicine}, year={1996}, volume={28}, pages={119-123} }