Circumsporozoite-Specific T Cell Responses in Children Vaccinated with RTS,S/AS01E and Protection against P falciparum Clinical Malaria

@inproceedings{Olotu2011CircumsporozoiteSpecificTC,
  title={Circumsporozoite-Specific T Cell Responses in Children Vaccinated with RTS,S/AS01E and Protection against P falciparum Clinical Malaria},
  author={Ally Ibrahim Olotu and Philippe J. Moris and Jedidah K Mwacharo and Johan Vekemans and Domtila Wangui Kimani and Michel H. Janssens and Oscar Kai and Erik Jongert and Marc J. J. Lievens and Amanda R. Leach and Tonya Villafana and Barbara M. Savarese and Kevin Marsh and Session Moderator Joe Cohen and Philip Bejon},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND RTS,S/AS01(E) is the lead candidate pre-erythrocytic malaria vaccine. In Phase IIb field trials the safety profile was acceptable and the efficacy was 53% (95%CI 31%-72%) for protecting children against clinical malaria caused by P. falciparum. We studied CS-specific T cell responses in order to identify correlates of protection. METHODS AND FINDINGS We used intracellular cytokine staining (for IL2, IFNγ, and TNFα), ex-vivo ELISPOTs (IFNγ and IL2) and IFNγ cultured ELISPOT assays… CONTINUE READING

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Distinct Helper T Cell Type 1 and 2 Responses Associated With Malaria Protection and Risk in RTS,S/AS01E Vaccinees.

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