Circulatory basis of fMRI signals: relationship between changes in the hemodynamic parameters and BOLD signal intensity.

@article{Seiyama2004CirculatoryBO,
  title={Circulatory basis of fMRI signals: relationship between changes in the hemodynamic parameters and BOLD signal intensity.},
  author={Akitoshi Seiyama and Junji Seki and Hiroki C. Tanabe and Ichiro Sase and Akira Takatsuki and Satoru Miyauchi and Hideo Eda and Shigeru Hayashi and Toshihide Imaruoka and Takeo Iwakura and Toshio Yanagida},
  journal={NeuroImage},
  year={2004},
  volume={21 4},
  pages={1204-14}
}
Blood oxygenation level-dependent functional magnetic resonance imaging (BOLD-fMRI) is widely used as a tool for functional brain mapping. During brain activation, increases in the regional blood flow lead to an increase in blood oxygenation and a decrease in paramagnetic deoxygenated hemoglobin (deoxy-Hb), causing an increase in the MR signal intensity at the site of brain activation. However, not a few studies using fMRI have failed to detect activation of areas that ought to have been… CONTINUE READING

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