Circulatory arrest as a model for studies of global ischemic injury and neuroprotection.

@article{Wiklund2005CirculatoryAA,
  title={Circulatory arrest as a model for studies of global ischemic injury and neuroprotection.},
  author={L. -M. Wiklund and Hari Shanker Sharma and Samar Basu},
  journal={Annals of the New York Academy of Sciences},
  year={2005},
  volume={1053},
  pages={205-19}
}
Despite many programs aimed at better immediate care of cardiac arrest victims, the subsequent mortality rate is high, with myocardial and central nervous system (CNS) injuries as the most common causes of death. Preclinical research is badly needed to produce a sound base for future clinical trials and possible improvements in clinical outcome. In our laboratory, we use piglets weighing approximately 25 kg. Ventricular fibrillation is produced by an AC current and left without treatment for 8… CONTINUE READING