Circulation of type 1 vaccine-derived poliovirus in the Philippines in 2001.

  title={Circulation of type 1 vaccine-derived poliovirus in the Philippines in 2001.},
  author={Hiroyuki Shimizu and Bruce R. Thorley and Fem Julia Paladin and Kerri Anne Brussen and Vicki Stambos and Lilly Yuen and Andi Utama and Yoshio Tano and Minetaro Arita and Hiromu Yoshida and Tetsuo Yoneyama and Agnes Benegas and Sigrun Roesel and Mark Pallansch and Olen Kew and Tatsuo Miyamura},
  journal={Journal of virology},
  volume={78 24},
In 2001, highly evolved type 1 circulating vaccine-derived poliovirus (cVDPV) was isolated from three acute flaccid paralysis patients and one contact from three separate communities in the Philippines. Complete genomic sequencing of these four cVDPV isolates revealed that the capsid region was derived from the Sabin 1 vaccine strain but most of the noncapsid region was derived from an unidentified enterovirus unrelated to the oral poliovirus vaccine (OPV) strains. The sequences of the cVDPV… CONTINUE READING
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