Circulation of cholesterol between lysosomes and the plasma membrane.

  title={Circulation of cholesterol between lysosomes and the plasma membrane.},
  author={Yvonne Lange and Jin Ye and T. Steck},
  journal={The Journal of biological chemistry},
  volume={273 30},
The cholesterol in the lysosomes of cultured human fibroblasts was determined to constitute approximately 6% of the cell total. This pool was enlarged by as much as 10-fold in Niemann-Pick type C cells. Certain amphiphiles (e.g. U18666A, progesterone, and imipramine) caused lysosomal cholesterol to increase to similarly high levels at a rate of approximately 0.8% of cell cholesterol/h. Lysosomal cholesterol accumulated even in the absence of exogenous lipoproteins. Furthermore, nearly all of… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
38 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 38 extracted citations

Similar Papers

Loading similar papers…