Circulation and Chemotaxis of Fetal Hematopoietic Stem Cells

@article{Christensen2004CirculationAC,
  title={Circulation and Chemotaxis of Fetal Hematopoietic Stem Cells},
  author={Julie Lejsgaard Christensen and Douglas E Wright and Amy J Wagers and Irving L Weissman},
  journal={PLoS Biology},
  year={2004},
  volume={2},
  pages={257 - 267}
}
The major site of hematopoiesis transitions from the fetal liver to the spleen and bone marrow late in fetal development. To date, experiments have not been performed to evaluate functionally the migration and seeding of hematopoietic stem cells (HSCs) during this period in ontogeny. It has been proposed that developmentally timed waves of HSCs enter the bloodstream only during distinct windows to seed the newly forming hematopoietic organs. Using competitive reconstitution assays to measure… CONTINUE READING

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