Circulating vitamin D levels and colorectal cancer risk: A meta-analysis and systematic review of case-control and prospective cohort studies.

  title={Circulating vitamin D levels and colorectal cancer risk: A meta-analysis and systematic review of case-control and prospective cohort studies.},
  author={Pablo Hern{\'a}ndez‐Alonso and Hatim Boughanem and Silvia Canudas and Nerea Becerra-Tom{\'a}s and Mar{\'i}a Fern{\'a}ndez de la Puente and Nancy Babio and Manuel Mac{\'i}as-Gonz{\'a}lez and Jordi Salas-Salvad{\'o}},
  journal={Critical reviews in food science and nutrition},
The associations between circulating vitamin D concentrations and total and site-specific colorectal cancer (CRC) incidence have been examined in several epidemiological studies with overall inconclusive findings. The aim of this systematic review and meta-analysis of both case-control and prospective cohort studies was to evaluate the association between CRC and circulating levels of vitamin D. The main exposure and outcome were circulating total 25(OH)D and CRC, respectively, in the overall… 
Vitamin D and Cancer: An Historical Overview of the Epidemiology and Mechanisms
The available mechanistic data support the global protective action of vitamin D against several important types of cancer.
A Narrative Review of the Evidence for Variations in Serum 25-Hydroxyvitamin D Concentration Thresholds for Optimal Health
The general finding is that optimal 25(OH)D concentrations to support health and wellbeing are above 30 ng/mL (75 nmol/L) for cardiovascular disease and all-cause mortality rate, whereas the thresholds for several other outcomes appear to range up to 40 or 50 ng/ mL.
Immune Response in Vitamin D Deficient Metastatic Colorectal Cancer Patients: A Player That Should Be Considered for Targeted Vitamin D Supplementation
The neutrophils-to-lymphocytes ratio, CD4+ T lymphocytes and B lymphocytes as being closely related to vitamin D status with an impact on immune response in patients with mCRC are identified and a vitamin D cut-off level is proposed.


Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations:a nested case-control study
The results of this large observational study indicate a strong inverse association between levels of pre-diagnostic 25-(OH)D concentration and risk of colorectal cancer in western European populations.
A nested case control study of plasma 25-hydroxyvitamin D concentrations and risk of colorectal cancer.
Support is provided for the inverse association between vitamin D and colorectal and, in particular, colon cancer risk by a nested case-control study within the Health Professionals Follow-up Study.
Pre-diagnostic vitamin D concentrations and cancer risks in older individuals: an analysis of cohorts participating in the CHANCES consortium
Limited support is provided for the hypothesis that vitamin D may have a major role in cancer development and prevention among European older adults by meta-analyses with individual participant data from three large population-based cohort studies.
Meta‐analysis of observational studies of serum 25‐hydroxyvitamin D levels and colorectal, breast and prostate cancer and colorectal adenoma
A consistent inverse relationship between serum 25‐hydroxyvitamin D levels and colorectal cancer was found and differences between cases and controls in the season of blood draw or in overweight/obesity or physical inactivity could not explain the results.
Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts
Higher circulating 25(OH)D was related to a statistically significant, substantially lower colorectal cancer risk in women and non-statistically significant lower risk in men and appears higher than current IOM recommendations.
Serum 25-hydroxyvitamin D and risks of colon and rectal cancer in Finnish men.
The results provide no evidence to support an inverse association between vitamin D status and colon or rectal cancer risk; instead, they suggest a positive association for colon cancer.
Effect of serum 25-hydroxyvitamin D level on lung, breast, colorectal and prostate cancers: a nested case-control study.
  • A. Acikgoz, D. Çımrın, G. Ergor
  • Medicine
    Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit
  • 2020
It was seen that low 25(OH)D levels were associated with a greater than threefold increased risk of lung cancer; no association was detected for breast, colorectal and prostate cancers.
The Association between Serum 25-Hydroxyvitamin D and Cancer Risk: Results from the Prospective KORA F4 Study
This study analyzed data from a population-based prospective cohort study including 2,003 initially cancer-free participants from the KORA F4 study with baseline serum 25-hydroxyvitamin D measurements to find no protective effect of 25(OH)D against developing cancer.