Circulating vascular endothelial growth factor concentrations in a case of pulmonary hypertrophic osteoarthropathy. Correlation with disease activity.

@article{Oln2004CirculatingVE,
  title={Circulating vascular endothelial growth factor concentrations in a case of pulmonary hypertrophic osteoarthropathy. Correlation with disease activity.},
  author={Francisco Ol{\'a}n and Margarita Portela and Carmen Navarro and Miguel Gaxiola and Luis H. Silveira and Victor M. Ruiz and Manuel Mart{\'i}nez-Lav{\'i}n},
  journal={The Journal of rheumatology},
  year={2004},
  volume={31 3},
  pages={614-6}
}
Vascular endothelial growth factor (VEGF) is a cytokine overexpressed in hypoxic and malignant pathologies. VEGF induces vascular hyperplasia, new bone formation, and edema. These histological abnormalities characterize hypertrophic osteoarthropathy. We describe a case of pulmonary hypertrophic osteoarthropathy with high circulating VEGF levels. Removal of the lung tumor led to a dramatic disappearance of the skeletal abnormalities and to reduction of circulating VEGF levels. Histochemical… CONTINUE READING

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