Circulating tumour tissue fragments in patients with pulmonary metastasis of clear cell renal cell carcinoma.

@article{KatsUgurlu2009CirculatingTT,
  title={Circulating tumour tissue fragments in patients with pulmonary metastasis of clear cell renal cell carcinoma.},
  author={Gursah Kats-Ugurlu and Ilse Roodink and Mirjam C.A. de Weijert and Dorien M. Tiemessen and Cathy Maass and Kiek C N Verrijp and Jeroen Awm van der Laak and Rob de Waal and Peter C R Mulders and Egbert Oosterwijk and W. O. J. L. Leenders},
  journal={The Journal of pathology},
  year={2009},
  volume={219 3},
  pages={287-93}
}
Tumour metastasis is the result of a complex sequence of events, including migration of tumour cells through stroma, proteolytic degradation of stromal and vessel wall elements, intravasation, transport through the circulation, extravasation and outgrowth at compatible sites in the body (the 'seed and soil' hypothesis). However, the high incidence of metastasis from various tumour types in liver and lung may be explained by a stochastic process as well, based on the anatomical relationship of… CONTINUE READING