Circulating tumour-associated plasma DNA represents an independent and informative predictor of prostate cancer.

  title={Circulating tumour-associated plasma DNA represents an independent and informative predictor of prostate cancer.},
  author={Felix K-H Chun and Imke Mueller and Imke Lange and Martin G. Friedrich and Andreas Erbersdobler and Pierre I. Karakiewicz and Markus Graefen and Klaus Pantel and Hartwig Huland and Heidi Schwarzenbach},
  journal={BJU international},
  volume={98 3},
OBJECTIVE To investigate whether preoperative plasma levels of free DNA can discriminate between men with localized prostate cancer and benign prostatic hyperplasia (BPH). PATIENTS AND METHODS In all, 161 referred patients suspicious for prostate cancer either by an elevated prostate-specific antigen (PSA) level and/or abnormal digital rectal examination (DRE) were included in this prospective study. Peripheral plasma was taken before prostate biopsy and genomic DNA was extracted from the… CONTINUE READING

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