Circulating tumor-derived DNA is shorter than somatic DNA in plasma.

Circulating tumor DNA (ctDNA) is now widely investigated as a biomarker in translational and clinical research (1). However, despite the growing field of clinical applications, the biology of ctDNA remains unclear. In trying to learn about the origins of ctDNA, nature provides us with very few clues. One of the important accessible parameters is the size of… (More)