Circulating tumor cells with a putative stem cell phenotype in peripheral blood of patients with breast cancer.

@article{Theodoropoulos2010CirculatingTC,
  title={Circulating tumor cells with a putative stem cell phenotype in peripheral blood of patients with breast cancer.},
  author={Panayiotis Theodoropoulos and Hara Polioudaki and Sofia I Agelaki and G Kallergi and Zacharenia Saridaki and Dimitrios Mavroudis and Vassilis Georgoulias},
  journal={Cancer letters},
  year={2010},
  volume={288 1},
  pages={99-106}
}
The CD44(+)/CD24(-/low) and ALDH1(+) cell phenotypes are associated with stemness and enhanced tumorigenic potential in breast cancer. We assessed the expression of CD44, CD24 and ALDH1 on tumor cells circulating in the peripheral blood (CTCs) of patients with metastatic breast cancer using triple-marker immunofluorescence microscopy. Among a total of 1439 CTCs identified in 20 (66.7%) out of 30 patients, 35.2% had the stem-like/tumorigenic phenotype CD44(+)/CD24(-/low), whereas 17.7% of the… CONTINUE READING

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