Circulating tumor cells in metastatic breast cancer: from prognostic stratification to modification of the staging system?

@article{Dawood2008CirculatingTC,
  title={Circulating tumor cells in metastatic breast cancer: from prognostic stratification to modification of the staging system?},
  author={Shaheenah Dawood and Kristine R. Broglio and Vicente Valero and James M. Reuben and Beverly Handy and Rabiul Islam and Summer Jackson and Gabriel N Hortobagyi and Herbert A. Fritsche and Massimo Cristofanilli},
  journal={Cancer},
  year={2008},
  volume={113 9},
  pages={2422-30}
}
BACKGROUND The aim of the current study was to assess the prognostic value of baseline circulating tumor cells (CTCs) in a large cohort of patients with newly diagnosed metastatic breast cancer (MBC). METHODS This retrospective study included 185 patients with newly diagnosed MBC evaluated between 2001 and 2007. CTCs were isolated and enumerated before patients started first-line treatment using the CellSearch system. Overall survival (OS) was calculated from the date of CTC measurement… CONTINUE READING

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