Circulating tumor cells in metastatic breast cancer: biologic staging beyond tumor burden.

@article{Cristofanilli2007CirculatingTC,
  title={Circulating tumor cells in metastatic breast cancer: biologic staging beyond tumor burden.},
  author={Massimo Cristofanilli and Kristine R. Broglio and Valentina Guarneri and Summer Jackson and Herbert A. Fritsche and Md. Rabiul Islam and Shaheenah Dawood and James Mwikya Reuben and S. C. Kau and J. M Espinosa Lara and S. Krishnamurthy and Naoto T Ueno and Gabriel N Hortobagyi and Vincente Valero},
  journal={Clinical breast cancer},
  year={2007},
  volume={7 6},
  pages={
          471-9
        }
}
BACKGROUND The detection of circulating tumor cells (CTCs) predicts overall survival in patients with metastatic breast cancer (MBC). However, it is unknown whether CTCs have superior value compared with other standard prognostic factors. We compared the prognostic significance of CTCs with clinical and laboratory measures of tumor burden and phenotypic subtype of disease. PATIENTS AND METHODS One hundred fifty-one patients with MBC evaluated between 2000 and 2006 were included in this… CONTINUE READING

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