Circulating tumor cells and response to chemotherapy in metastatic breast cancer: SWOG S0500.

@article{Smerage2014CirculatingTC,
  title={Circulating tumor cells and response to chemotherapy in metastatic breast cancer: SWOG S0500.},
  author={Jeffrey B. Smerage and William Eric Barlow and Gabriel N Hortobagyi and Eric P. Winer and Brian R. Leyland-Jones and Gordan Srkalovi{\'c} and Sheela Tejwani and Anne F. Schott and Mark Allen O'Rourke and Danika L. Lew and Gerald V. Doyle and Julie R. Gralow and Robert B. Livingston and Daniel F. Hayes},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2014},
  volume={32 31},
  pages={3483-9}
}
PURPOSE Increased circulating tumor cells (CTCs; five or more CTCs per 7.5 mL of whole blood) are associated with poor prognosis in metastatic breast cancer (MBC). A randomized trial of patients with persistent increase in CTCs tested whether changing chemotherapy after one cycle of first-line chemotherapy would improve the primary outcome of overall survival (OS). PATIENTS AND METHODS Patients with MBC who did not have increased CTCs at baseline remained on initial therapy until progression… CONTINUE READING
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