Circulating tumor cells: approaches to isolation and characterization

  title={Circulating tumor cells: approaches to isolation and characterization},
  author={Min Yu and Shannon L. Stott and Mehmet Toner and S. Maheswaran and Daniel A. Haber},
  booktitle={The Journal of cell biology},
Circulating tumor cells (CTCs) shed from primary and metastatic cancers are admixed with blood components and are thus rare, making their isolation and characterization a major technological challenge. CTCs hold the key to understanding the biology of metastasis and provide a biomarker to noninvasively measure the evolution of tumor genotypes during treatment and disease progression. Improvements in technologies to yield purer CTC populations amenable to better cellular and molecular… CONTINUE READING
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