Circulating tumor cell (CTC) count and epithelial growth factor receptor expression on CTCs as biomarkers for cetuximab efficacy in advanced colorectal cancer.

@article{Kuboki2013CirculatingTC,
  title={Circulating tumor cell (CTC) count and epithelial growth factor receptor expression on CTCs as biomarkers for cetuximab efficacy in advanced colorectal cancer.},
  author={Yasutoshi Kuboki and Satoshi Matsusaka and Sayuri Minowa and Harumi Shibata and Mitsukuni Suenaga and Eiji Shinozaki and Nobuyuki Mizunuma and Masashi Ueno and Toshiharu Yamaguchi and Kiyohiko Hatake},
  journal={Anticancer research},
  year={2013},
  volume={33 9},
  pages={3905-10}
}
BACKGROUND/AIM The purpose of this study was to establish whether CTC count and epidermal growth factor receptor (EGFR) expression in CTCs predicted outcome in patients with advance colorectal cancer (ACC) receiving cetuximab as third-line treatment. PATIENTS AND METHODS Between October 2008 and March 2011, 63 patients with KRAS wild-type ACC were treated with cetuximab-containing chemotherapy at the Cancer Institute Hospital. We measured the CTC count and EGFR expression on CTCs using the… CONTINUE READING
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