Circulating transforming growth factor-β as a prognostic biomarker in Marfan syndrome.

@article{Franken2013CirculatingTG,
  title={Circulating transforming growth factor-β as a prognostic biomarker in Marfan syndrome.},
  author={Romy Franken and Alexander W. den Hartog and Vivian de Waard and Leo J. Engele and Teodora Radonic and Ren{\'e} Lutter and Janneke Timmermans and Arthur J. H. A. Scholte and Maarten P. van den Berg and Aeilko H. Zwinderman and Maarten Groenink and Barbara Mulder},
  journal={International journal of cardiology},
  year={2013},
  volume={168 3},
  pages={2441-6}
}
BACKGROUND Patients with Marfan syndrome (MFS) are at risk for cardiovascular disease. Marfan associated mutations in the FBN1 gene lead to increased transforming growth factor-β (TGF-β) activation. The aim of this study was to investigate the role of plasma TGF-β as a biomarker for progressive aortic root dilatation and dissection. METHODS Plasma TGF-β level and aortic root diameter by means of echocardiography were assessed in 99 MFS patients. After 38 months of follow-up measurement of the… CONTINUE READING

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