Circulating succinate is elevated in rodent models of hypertension and metabolic disease.

  title={Circulating succinate is elevated in rodent models of hypertension and metabolic disease.},
  author={N. Sadagopan and Wenlin Li and Steven L. Roberds and Terry Major and Gregory M. Preston and Ying Di Yu and Michael A. Tones},
  journal={American journal of hypertension},
  volume={20 11},
BACKGROUND Recent evidence suggests that succinate, long known as an intermediate in the citric acid cycle, may also have a role as a signaling molecule through GPR91 and that activation of this receptor results in blood pressure (BP) elevation via the renin-angiotensin system. We sought to test the hypothesis that GPR91 contributes to BP elevation in hypertension. In addition we investigated whether elevated succinate in diabetes could contribute to the increased rate of gluconeogenesis in… CONTINUE READING


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