Circulating soluble leptin receptor and free leptin index during childhood, puberty, and adolescence.

@article{Kratzsch2002CirculatingSL,
  title={Circulating soluble leptin receptor and free leptin index during childhood, puberty, and adolescence.},
  author={J{\"u}rgen Kratzsch Kratzsch and Alexander Lammert and A Bottner and Barbara Seidel and Grit Mueller and Joachim Thiery and Johannes Hebebrand and Wieland Kiess},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2002},
  volume={87 10},
  pages={4587-94}
}
Leptin is bound in human blood by a high affinity binding protein, which appears to be identical with the soluble leptin receptor (sOB-R). Using a ligand-mediated immunofunctional assay for the determination of serum sOB-R, we investigated its course during childhood, puberty, and adolescence in a large cohort of 581 healthy children and adolescents and a small group of 13 patients with anorexia nervosa. In the first years of life, sOB-R is detectable in remarkably high concentrations… CONTINUE READING
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